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Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities
Amphotericin B is the archetype for small molecules that form transmembrane ion channels. However, despite extensive study for more than five decades, even the most basic features of this channel structure and its contributions to the antifungal activities of this natural product have remained uncle...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084054/ https://ncbi.nlm.nih.gov/pubmed/21368185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015023108 |
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