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Is tau a suitable therapeutical target in tauopathies?

Tau is an intracellular protein, found mainly in neurons, but it can also be found in the extracellular space in pathological situations. Here we discuss whether intracellular tau, in aggregated form or modified by phosphorylation, could be toxic inside a neuron. On the other hand, it has been propo...

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Hlavní autoři: de Barreda, Elena Gomez, Avila, Jesús
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Co., Limited 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083962/
https://ncbi.nlm.nih.gov/pubmed/21540993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4331/wjbc.v1.i5.81
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