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A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: advantages of an asymmetric design.

Trans-cleaving hammerhead ribozymes with long target-specific antisense sequences flanking the catalytic domain share some features with conventional antisense RNA and are therefore termed 'catalytic antisense RNAs'. Sequences 5' to the catalytic domain form helix I and sequences 3�...

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Autors principals: Tabler, M, Homann, M, Tzortzakaki, S, Sczakiel, G
Format: Artigo
Idioma:Inglês
Publicat: 1994
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC308396/
https://ncbi.nlm.nih.gov/pubmed/7937118
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