A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: advantages of an asymmetric design.

Benzer Materyaller

• Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells.
  Yazar:: Homann, M, ve diğerleri
  Baskı/Yayın Bilgisi: (1994)
• Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1.
  Yazar:: Homann, M, ve diğerleri
  Baskı/Yayın Bilgisi: (1993)
• The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.
  Yazar:: Hormes, R, ve diğerleri
  Baskı/Yayın Bilgisi: (1997)
• A spermidine-induced conformational change of long-armed hammerhead ribozymes: ionic requirements for fast cleavage kinetics.
  Yazar:: Hammann, C, ve diğerleri
  Baskı/Yayın Bilgisi: (1997)
• Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.
  Yazar:: Beigelman, L, ve diğerleri
  Baskı/Yayın Bilgisi: (1995)