5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates.

Recent studies with 8-oxodeoxyguanosine triphosphate (8-oxodGTP) have suggested that incorporation of oxidized nucleotides from the precursor pool into DNA may have deleterious effects. Here we show that 5-hydroxydeoxycytosine triphosphate (5-OHdCTP) and 5-hydroxydeoxyuridine triphosphate (5-OHdUTP)...

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Autores principales: Purmal, A A, Kow, Y W, Wallace, S S
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC308392/
https://ncbi.nlm.nih.gov/pubmed/7937115
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