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Adoptive transfer of HER2/neu-specific T cells expanded with alternating gamma chain cytokines mediate tumor regression when combined with the depletion of myeloid-derived suppressor cells

Adoptive immunotherapy (AIT) using ex vivo-expanded HER-2/neu-specific T cells has shown initial promising results against disseminated tumor cells in the bone marrow. However, it has failed to promote objective responses against primary tumors. We report for the first time that alternating gamma ch...

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Detalhes bibliográficos
Main Authors: Morales, Johanna K., Kmieciak, Maciej, Graham, Laura, Feldmesser, Marta, Bear, Harry D., Manjili, Masoud H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083860/
https://ncbi.nlm.nih.gov/pubmed/18979098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0609-z
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