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Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

Type 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to a loss of T cell tolerance to β cells and consequent T cell–mediated destruction of insulin-producing islet cells. Genetic studies have suggested that PRSS16 is linked to a diabetes...

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Detalhes bibliográficos
Main Authors: Viret, Christophe, Leung-Theung-Long, Stéphane, Serre, Laurent, Lamare, Camille, Vignali, Dario A.A., Malissen, Bernard, Carrier, Alice, Guerder, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083765/
https://ncbi.nlm.nih.gov/pubmed/21505262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43314
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