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Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice
Type 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to a loss of T cell tolerance to β cells and consequent T cell–mediated destruction of insulin-producing islet cells. Genetic studies have suggested that PRSS16 is linked to a diabetes...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083765/ https://ncbi.nlm.nih.gov/pubmed/21505262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43314 |
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