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Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha.

NF-kappa B was first identified as a postive regulator which bound to a 10 bp sequence in the first intron of the Ig kappa light chain gene. Further characterization of this transcription factor has revealed that NF-kappa B is kept from binding to its consensus sequence by its inhibitor, IkB-alpha,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ito, C Y, Kazantsev, A G, Baldwin, A S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC308363/
https://ncbi.nlm.nih.gov/pubmed/7937093
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