Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha.
NF-kappa B was first identified as a postive regulator which bound to a 10 bp sequence in the first intron of the Ig kappa light chain gene. Further characterization of this transcription factor has revealed that NF-kappa B is kept from binding to its consensus sequence by its inhibitor, IkB-alpha,...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
1994
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| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937093/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.18.3787 |
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