Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog

Geminin is an essential cell-cycle protein that is only present from S phase to early mitosis in metazoan somatic cells [1, 2]. Genetic ablation of geminin in the mouse results in preimplantation embryonic lethality because pluripotent cells fail to form and all cells differentiate to trophoblast [3...

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Autori principali: Yang, Valerie S., Carter, Stephanie A., Hyland, Sarah J., Tachibana-Konwalski, Kikuë, Laskey, Ronald A., Gonzalez, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083515/
https://ncbi.nlm.nih.gov/pubmed/21497086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.03.026
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