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Aerobic Pd-Catalyzed sp(3) C–H Olefination: A Route to Both N-Heterocyclic Scaffolds and Alkenes

This communication describes a new method for the Pd/polyoxometalate-catalyzed aerobic olefination of unactivated sp(3) C–H bonds. Nitrogen heterocycles serve as directing groups, and air is used as the terminal oxidant. The products undergo reversible intramolecular Michael addition, which protects...

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Autori principali: Stowers, Kara J., Fortner, Kevin C., Sanford, Melanie S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083468/
https://ncbi.nlm.nih.gov/pubmed/21476513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2015586
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