PKB/SGK-Resistant GSK3 Enhances Phosphaturia and Calciuria

Insulin and IGF1-dependent signaling activates protein kinase B and serum and glucocorticoid inducible kinase (PKB/SGK), which together phosphorylate and inactivate glycogen synthase kinase GSK3. Because insulin and IGF1 increase renal tubular calcium and phosphorus reabsorption, we examined GSK3 re...

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Main Authors: Föller, Michael, Kempe, Daniela S., Boini, Krishna M., Pathare, Ganesh, Siraskar, Balasaheb, Capuano, Paola, Alesutan, Ioana, Sopjani, Mentor, Stange, Gerti, Mohebbi, Nilufar, Bhandaru, Madhuri, Ackermann, Teresa F., Judenhofer, Martin S., Pichler, Bernd J., Biber, Jürg, Wagner, Carsten A., Lang, Florian
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2011
Assuntos:
Basic Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083309/
https://ncbi.nlm.nih.gov/pubmed/21493770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010070757
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