PKB/SGK-Resistant GSK3 Enhances Phosphaturia and Calciuria

Insulin and IGF1-dependent signaling activates protein kinase B and serum and glucocorticoid inducible kinase (PKB/SGK), which together phosphorylate and inactivate glycogen synthase kinase GSK3. Because insulin and IGF1 increase renal tubular calcium and phosphorus reabsorption, we examined GSK3 re...

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Main Authors: Föller, Michael, Kempe, Daniela S., Boini, Krishna M., Pathare, Ganesh, Siraskar, Balasaheb, Capuano, Paola, Alesutan, Ioana, Sopjani, Mentor, Stange, Gerti, Mohebbi, Nilufar, Bhandaru, Madhuri, Ackermann, Teresa F., Judenhofer, Martin S., Pichler, Bernd J., Biber, Jürg, Wagner, Carsten A., Lang, Florian
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2011
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083309/
https://ncbi.nlm.nih.gov/pubmed/21493770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010070757
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