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The Essential Ubc4/Ubc5 Function in Yeast Is HECT E3-dependent, and RING E3-dependent Pathways Require Only Monoubiquitin Transfer by Ubc4

The ubiquitin (Ub)-conjugating enzymes Ubc4 and Ubc5 are involved in a variety of ubiquitination pathways in yeast, including Rsp5- and anaphase-promoting complex (APC)-mediated pathways. We have found the double deletion of UBC4 and UBC5 genes in yeast to be lethal. To investigate the essential pat...

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Hlavní autoři: Stoll, Kate E., Brzovic, Peter S., Davis, Trisha N., Klevit, Rachel E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083232/
https://ncbi.nlm.nih.gov/pubmed/21357418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.203968
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