Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

Hypomorphic ADAM17(ex/ex) mice showed defects in mucosal regeneration due to inefficient enhanced GFR shedding. ADAM17 is the main sheddase of interleukin-6 receptor (IL-6R) to induce IL-6 trans-signaling. However, serum levels of soluble murine IL-6R were not reduced in ADAM17(ex/ex) mice, and muri...

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Bibliographische Detailangaben
Hauptverfasser: Garbers, Christoph, Jänner, Nathalie, Chalaris, Athena, Moss, Marcia L., Floss, Doreen M., Meyer, Dörte, Koch-Nolte, Friedrich, Rose-John, Stefan, Scheller, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083187/
https://ncbi.nlm.nih.gov/pubmed/21454673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229393
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