CIN85 Modulates the Down-regulation of FcγRIIa Expression and Function by c-Cbl in a PKC-dependent Manner in Human Neutrophils

We previously described a non-classical mechanism that arrests FcγRIIa signaling in human neutrophils once engaged by immune complexes or opsonized pathogens. The engagement of FcγRIIa leads to its ubiquitination by the ubiquitin ligase c-Cbl and degradation by the proteasome. Herein, we further exa...

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Main Authors: Marois, Louis, Vaillancourt, Myriam, Paré, Guillaume, Gagné, Valérie, Fernandes, Maria J. G., Rollet-Labelle, Emmanuelle, Naccache, Paul H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083175/
https://ncbi.nlm.nih.gov/pubmed/21372129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213660
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