Cross-linking of IgGs bound on circulating neutrophils leads to an activation of endothelial cells: possible role of rheumatoid factors in rheumatoid arthritis-associated vascular dysfunction

BACKGROUND: Rheumatoid arthritis is characterized by the presence of circulating auto-antibodies, including rheumatoid factors, which recognize the Fc portion of IgGs. The neutrophil is the most abundant circulating leukocyte and it expresses high levels of FcγRs on its surface. The aim of the prese...

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Detalhes bibliográficos
Main Authors: Rollet-Labelle, Emmanuelle, Vaillancourt, Myriam, Marois, Louis, Newkirk, Marianna M, Poubelle, Patrice E, Naccache, Paul H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734015/
https://ncbi.nlm.nih.gov/pubmed/23902799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-10-27
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