Expression of CD44 3′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis

The non-coding 3′-untranslated region (UTR) plays an important role in the regulation of microRNA (miRNA) functions, since it can bind and inactivate multiple miRNAs. Here, we show the 3′-UTR of CD44 is able to antagonize cytoplasmic miRNAs, and result in the increased translation of CD44 and downst...

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Main Authors: Jeyapalan, Zina, Deng, Zhaoqun, Shatseva, Tatiana, Fang, Ling, He, Chengyan, Yang, Burton B.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082902/
https://ncbi.nlm.nih.gov/pubmed/21149267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1003
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