Abcg2 Overexpression Represents a Novel Mechanism for Acquired Resistance to the Multi-Kinase Inhibitor Danusertib in BCR-ABL-Positive Cells In Vitro

The success of Imatinib (IM) therapy in chronic myeloid leukemia (CML) is compromised by the development of IM resistance and by a limited IM effect on hematopoietic stem cells. Danusertib (formerly PHA-739358) is a potent pan-aurora and ABL kinase inhibitor with activity against known BCR-ABL mutat...

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Detalhes bibliográficos
Main Authors: Balabanov, Stefan, Gontarewicz, Artur, Keller, Gunhild, Raddrizzani, Laura, Braig, Melanie, Bosotti, Roberta, Moll, Jürgen, Jost, Edgar, Barett, Christine, Rohe, Imke, Bokemeyer, Carsten, Holyoake, Tessa L., Brümmendorf, Tim H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082549/
https://ncbi.nlm.nih.gov/pubmed/21541334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019164
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