An Electrochemical Supersandwich Assay for Sensitive and Selective DNA Detection in Complex Matrices

In a traditional sandwich assay, a DNA target hybridizes to a single copy of the signal probe. Here we employ a modified signal probe containing a methylene blue (a redox moiety) label and a “sticky end.” When a DNA target hybridizes this signal probe, the sticky end remains free to hybridize anothe...

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Main Authors: Xia, Fan, White, Ryan J., Zuo, Xiaolei, Patterson, Adriana, Xiao, Yi, Kang, Di, Gong, Xiong, Plaxco, Kevin W., Heeger, Alan J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082473/
https://ncbi.nlm.nih.gov/pubmed/20873767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja104998m
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