Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

BACKGROUND: Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism. Included among these genes is Dgcr8, which encodes an RNA-binding protein required for microR...

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Bibliographic Details
Main Authors: Schofield, Claude M, Hsu, Ruby, Barker, Alison J, Gertz, Caitlyn C, Blelloch, Robert, Ullian, Erik M
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082233/
https://ncbi.nlm.nih.gov/pubmed/21466685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1749-8104-6-11
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