Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex

BACKGROUND: Neuronal phenotypes associated with hemizygosity of individual genes within the 22q11.2 deletion syndrome locus hold potential towards understanding the pathogenesis of schizophrenia and autism. Included among these genes is Dgcr8, which encodes an RNA-binding protein required for microR...

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Main Authors: Schofield, Claude M, Hsu, Ruby, Barker, Alison J, Gertz, Caitlyn C, Blelloch, Robert, Ullian, Erik M
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082233/
https://ncbi.nlm.nih.gov/pubmed/21466685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1749-8104-6-11
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