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Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes

BACKGROUND: A gene's position in regulatory, protein interaction or metabolic networks can be predictive of the strength of purifying selection acting on it, but these relationships are neither universal nor invariably strong. Following work in bacteria, fungi and invertebrate animals, we explo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hudson, Corey M, Conant, Gavin C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082228/
https://ncbi.nlm.nih.gov/pubmed/21470417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-11-89
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