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Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins.

The HIV-1 regulatory proteins tat and rev are both RNA binding proteins which recognize sequences in duplex RNA which are close to structural distortions. Here we identify phosphate contacts which are critical for each binding reaction by use of a new method. Model RNA binding sites are constructed...

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Détails bibliographiques
Auteurs principaux: Pritchard, C E, Grasby, J A, Hamy, F, Zacharek, A M, Singh, M, Karn, J, Gait, M J
Format: Artigo
Langue:Inglês
Publié: 1994
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC308214/
https://ncbi.nlm.nih.gov/pubmed/8041622
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