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Cyclic AMP-Mediated Cyst Expansion
In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The proliferative effect of cAMP in PKD is unique in that cAMP is anti-mitogenic in normal renal epithelial cells. This phenotypic...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081913/ https://ncbi.nlm.nih.gov/pubmed/21118718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.11.005 |
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