Long-Term Cardiac proBNP Gene Delivery Prevents the Development of Hypertensive Heart Disease in Spontaneously Hypertensive Rats

BACKGROUND: Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP lowering, anti-fibrotic and anti-hypertrophic properties, which makes BNP an attractive agent for a...

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Main Authors: Cataliotti, Alessandro, Tonne, Jason M., Bellavia, Diego, Martin, Fernando L., Oehler, Elise A., Harders, Gerald E., Campbell, Jarryd M., Peng, Kaw-Whye, Russell, Steve J., Malatino, Lorenzo S., Burnett, John C., Ikeda, Yasuhiro
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081597/
https://ncbi.nlm.nih.gov/pubmed/21403100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.981720
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