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Autocatalytic Intramolecular Isopeptide Bond Formation in Gram-Positive Bacterial Pili: A QM/MM Simulation

Gram-positive pathogens possess external pili or fimbrae with which they adhere to host cells during the infection process. Unusual dual intramolecular isopeptide bonds between Asn and Lys side chains within the N-terminal and C-terminal domains of the pilus subunits have been observed initially in...

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Autors principals: Hu, Xiangqian, Hu, Hao, Melvin, Jeffrey A., Clancy, Kathleen W., McCafferty, Dewey G., Yang, Weitao
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081525/
https://ncbi.nlm.nih.gov/pubmed/21142157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja107513t
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