Murine Lupus Susceptibility Locus Sle2 Activates DNA-Reactive B Cells through Two Sub-Loci with Distinct Phenotypes

The NZM2410-derived Sle2 lupus susceptibility locus induces an abnormal B cell differentiation which most prominently leads to the expansion of autoreactive B1a cells. We have mapped the expansion of B1a cells to three Sle2 sub-loci, Sle2a, Sle2b, and Sle2c. Sle2 also enhances the breach of B cell t...

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Bibliografiske detaljer
Main Authors: Zeumer, Leilani, Sang, Allison, Niu, Haitao, Morel, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081373/
https://ncbi.nlm.nih.gov/pubmed/21270826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2010.69
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