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Mature Peripheral RPE Cells Have an Intrinsic Capacity to Proliferate; A Potential Regulatory Mechanism for Age-Related Cell Loss

BACKGROUND: Mammalian peripheral retinal pigmented epithelium (RPE) cells proliferate throughout life, while central cells are senescent. It is thought that some peripheral cells migrate centrally to correct age-related central RPE loss. METHODOLOGY/PRINCIPAL FINDINGS: We ask whether this proliferat...

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Detalhes bibliográficos
Main Authors: Kokkinopoulos, Ioannis, Shahabi, Golnaz, Colman, Alan, Jeffery, Glen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081302/
https://ncbi.nlm.nih.gov/pubmed/21526120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018921
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