Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Epigenetic changes in gene expression play a role in the development of diabetic complications, including nephropathy. Histone deacetylases (HDACs) are a group of enzymes that exert epigenetic effects by altering the acetylation status of histone and nonhistone proteins. In the current study, we inv...

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Главные авторы: Advani, Andrew, Huang, Qingling, Thai, Kerri, Advani, Suzanne L., White, Kathryn E., Kelly, Darren J., Yuen, Darren A., Connelly, Kim A., Marsden, Philip A., Gilbert, Richard E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2011
Предметы:
Regular Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081208/
https://ncbi.nlm.nih.gov/pubmed/21514434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.044
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