Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage: A Therapeutic Target of PPARγ

Aldosterone (Aldo) causes podocyte damage by an unknown mechanism. We examined the role of mitochondrial dysfunction (MtD) in Aldo-treated podocytes in vitro and in vivo. Exposure of podocytes to Aldo reduced nephrin expression dose dependently, accompanied by increased production of reactive oxygen...

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Detalhes bibliográficos
Main Authors: Zhu, Chunhua, Huang, Songming, Yuan, Yanggang, Ding, Guixia, Chen, Ronghua, Liu, Bicheng, Yang, Tianxin, Zhang, Aihua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081205/
https://ncbi.nlm.nih.gov/pubmed/21514419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.029
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