CCN3 Impairs Osteoblast and Stimulates Osteoclast Differentiation to Favor Breast Cancer Metastasis to Bone

Bone is a preferred site for breast cancer metastasis, causing pain, fractures, spinal cord compressions, and hypercalcemia, all of which can significantly diminish the patient's quality of life. We identified CCN3 as a novel factor that is highly expressed in bone metastatic breast cancer cell...

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Hlavní autoři: Ouellet, Véronique, Tiedemann, Kerstin, Mourskaia, Anna, Fong, Jenna E., Tran-Thanh, Danh, Amir, Eitan, Clemons, Mark, Perbal, Bernard, Komarova, Svetlana V., Siegel, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081179/
https://ncbi.nlm.nih.gov/pubmed/21514448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.033
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