Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

BACKGROUND: IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis and other atopic diseases; therefore, filaggrin is a candidate gene in the etiol...

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Main Authors: Brown, Sara J., Asai, Yuka, Cordell, Heather J., Campbell, Linda E., Zhao, Yiwei, Liao, Haihui, Northstone, Kate, Henderson, John, Alizadehfar, Reza, Ben-Shoshan, Moshe, Morgan, Kenneth, Roberts, Graham, Masthoff, Laury J.N., Pasmans, Suzanne G.M.A., van den Akker, Peter C., Wijmenga, Cisca, Hourihane, Jonathan O’B., Palmer, Colin N.A., Lack, Gideon, Clarke, Ann, Hull, Peter R., Irvine, Alan D., McLean, W. H. Irwin
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2011
Assuntos:
Special section: Food allergy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081065/
https://ncbi.nlm.nih.gov/pubmed/21377035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.01.031
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