Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination

The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, the activated Akt is subjected to other regulatory events, including ubiquitinat...

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Bibliografiske detaljer
Main Authors: Jo, Hakryul, Lo, Pang-Kuo, Li, Yitang, Loison, Fabien, Green, Sarah, Wang, Jake, Silberstein, Leslie E., Ye, Keqiang, Chen, Hexin, Luo, Hongbo R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081014/
https://ncbi.nlm.nih.gov/pubmed/21464312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019062108
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