Altering α-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism

BACKGROUND: The envelope glycoprotein of lymphocytic choriomeningitis virus (LCMV) can efficiently pseudotype lentiviral vectors. Some strains of LCMV exploit high affinity interactions with α-dystroglycan (α-DG) to bind to cell surfaces and subsequently fuse in low pH endosomes. LCMV strains with l...

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Autori principali: Dylla, Douglas E, Xie, Litao, Michele, Daniel E, Kunz, Stefan, McCray, Paul B
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080791/
https://ncbi.nlm.nih.gov/pubmed/21477292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-9-8
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