Lentivirus Vectors Pseudotyped with Filoviral Envelope Glycoproteins Transduce Airway Epithelia from the Apical Surface Independently of Folate Receptor Alpha

The practical application of gene therapy as a treatment for cystic fibrosis is limited by poor gene transfer efficiency with vectors applied to the apical surface of airway epithelia. Recently, folate receptor alpha (FRα), a glycosylphosphatidylinositol-linked surface protein, was reported to be a...

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Autors principals: Sinn, Patrick L., Hickey, Melissa A., Staber, Patrick D., Dylla, Douglas E., Jeffers, Scott A., Davidson, Beverly L., Sanders, David A., McCray, Jr., Paul B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC154009/
https://ncbi.nlm.nih.gov/pubmed/12719583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5902-5910.2003
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