The loop-less (tm)Cdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2

BACKGROUND: The S73/S97/loop motif is a hallmark of the Cdc34 family of E2 ubiquitin-conjugating enzymes that together with the SCF E3 ubiquitin ligases promote degradation of proteins involved in cell cycle and growth regulation. The inability of the loop-less (Δ12)Cdc34 mutant to support growth wa...

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Detalhes bibliográficos
Main Authors: Lass, Agnieszka, Cocklin, Ross, Scaglione, Kenneth M, Skowyra, Michael, Korolev, Sergey, Goebl, Mark, Skowyra, Dorota
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080790/
https://ncbi.nlm.nih.gov/pubmed/21453497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1747-1028-6-7
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