SCF E3-Mediated Autoubiquitination Negatively Regulates Activity of Cdc34 E2 but Plays a Nonessential Role in the Catalytic Cycle In Vitro and In Vivo

One of the several still unexplained aspects of the mechanism by which the Cdc34/SCF RING-type ubiquitin ligases work is the marked stimulation of Cdc34 autoubiquitination, a phenomenon of unknown mechanism and significance. In in vitro experiments with single-lysine-containing Cdc34 mutant proteins...

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Main Authors: Scaglione, K. Matthew, Bansal, Parmil K., Deffenbaugh, Andrew E., Kiss, Alexi, Moore, Johnnie M., Korolev, Sergey, Cocklin, Ross, Goebl, Mark, Kitagawa, Katsumi, Skowyra, Dorota
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952114/
https://ncbi.nlm.nih.gov/pubmed/17562869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01555-06
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