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A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement

OBJECTIVE: Common variants in PDE8B are associated with TSH but apparently without any effect on thyroid hormone levels that is difficult to explain. Furthermore, the stability of the association has not been examined in longitudinal studies or in patients on levothyroxine (l-T(4)). DESIGN: Totally,...

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Detalhes bibliográficos
Main Authors: Taylor, Peter N, Panicker, Vijay, Sayers, Adrian, Shields, Beverley, Iqbal, Ahmed, Bremner, Alexandra P, Beilby, John P, Leedman, Peter J, Hattersley, Andrew T, Vaidya, Bijay, Frayling, Timothy, Evans, Jonathan, Tobias, Jonathan H, Timpson, Nicholas J, Walsh, John P, Dayan, Colin M
Formato: Artigo
Idioma:Inglês
Publicado em: BioScientifica 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080745/
https://ncbi.nlm.nih.gov/pubmed/21317282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-10-0938
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