The Effect of Survival Bias on Case-Control Genetic Association Studies of Highly Lethal Diseases

BACKGROUND: Survival bias is the phenomenon by which individuals are excluded from analysis of a trait because of mortality related to the expression of that trait. In genetic association studies, variants increasing risk for disease onset as well as risk of disease-related mortality (lethality) cou...

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Main Authors: Anderson, Christopher D., Nalls, Michael A., Biffi, Alessandro, Rost, Natalia S., Greenberg, Steven M., Singleton, Andrew B., Meschia, James F., Rosand, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080449/
https://ncbi.nlm.nih.gov/pubmed/21292865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.110.957928
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