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Multiple Wnt/ß-Catenin Responsive Enhancers Align with the MYC Promoter through Long-Range Chromatin Loops
Inappropriate activation of c-Myc (MYC) gene expression by the Wnt/ß-catenin signaling pathway is required for colorectal carcinogenesis. The elevated MYC levels in colon cancer cells are attributed in part to ß-catenin/TCF4 transcription complexes that are assembled at proximal Wnt/ß-catenin respon...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2011
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080403/ https://ncbi.nlm.nih.gov/pubmed/21533051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018966 |
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