Proline-Rich Tyrosine Kinase 2 (Pyk2) Promotes Cell Motility of Hepatocellular Carcinoma through Induction of Epithelial to Mesenchymal Transition

AIMS: Proline-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase of the focal adhesion kinase (FAK) family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients. Forced overexpression of Pyk2 can promote the proliferation and invasion of HCC cells. In...

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Main Authors: Sun, Chris K., Ng, Kevin T., Lim, Zophia X., Cheng, Qiao, Lo, Chung Mau, Poon, Ronnie T., Man, Kwan, Wong, Nathalie, Fan, Sheung Tat
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080371/
https://ncbi.nlm.nih.gov/pubmed/21533080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018878
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