Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

Rho GTPases impact a number of activities important for oncogenesis. Here we describe a small molecule inhibitor which blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma cells, without affecting normal cells. We identif...

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Huvudupphovsmän: Wang, Jian-Bin, Erickson, Jon W., Fuji, Reina, Ramachandran, Sekar, Gao, Ping, Dinavahi, Ramani, Wilson, Kristin F., Ambrosio, Andre L. B., Dias, Sandra M. G., Dang, Chi V., Cerione, Richard A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078749/
https://ncbi.nlm.nih.gov/pubmed/20832749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.08.009
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