Autophagy-deficient mice develop multiple liver tumors

Autophagy is a major pathway for degradation of cytoplasmic proteins and organelles, and has been implicated in tumor suppression. Here, we report that mice with systemic mosaic deletion of Atg5 and liver-specific Atg7(−/−) mice develop benign liver adenomas. These tumor cells originate autophagy-de...

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Bibliografiske detaljer
Main Authors: Takamura, Akito, Komatsu, Masaaki, Hara, Taichi, Sakamoto, Ayako, Kishi, Chieko, Waguri, Satoshi, Eishi, Yoshinobu, Hino, Okio, Tanaka, Keiji, Mizushima, Noboru
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078705/
https://ncbi.nlm.nih.gov/pubmed/21498569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2016211
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