Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

Satellite cells (SCs) sustain muscle growth and empower adult skeletal muscle with vigorous regenerative abilities. Here, we report that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in both Pax7(+)/Myf5(−) stem cells and Pax7(+)/Myf5(+) committed myogenic pre...

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Hauptverfasser: Juan, Aster H., Derfoul, Assia, Feng, Xuesong, Ryall, James G., Dell'Orso, Stefania, Pasut, Alessandra, Zare, Hossein, Simone, James M., Rudnicki, Michael A., Sartorelli, Vittorio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2011
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078704/
https://ncbi.nlm.nih.gov/pubmed/21498568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2027911
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