Reduced replication capacity of NL4-3 recombinant viruses encoding RT-Integrase sequences from HIV-1 elite controllers

BACKGROUND: Identifying viral and host determinants of HIV-1 elite control may help inform novel therapeutic and/or vaccination strategies. Previously, we observed decreased replication capacity in controller-derived viruses suggesting that fitness consequences of HLA class I-associated escape mutat...

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Main Authors: Brumme, Zabrina L., Li, Chun, Miura, Toshiyuki, Sela, Jennifer, Rosato, Pamela C., Brumme, Chanson J., Markle, Tristan J., Martin, Eric, Block, Brian L., Trocha, Alicja, Kadie, Carl M., Allen, Todd M., Pereyra, Florencia, Heckerman, David, Walker, Bruce D., Brockman, Mark A.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078702/
https://ncbi.nlm.nih.gov/pubmed/21124229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3181fe9450
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