Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility

BACKGROUND: Mitochondrial DNA (mtDNA) mutations occur in head and neck squamous cell carcinoma (HNSCC) and are most frequently detected in the displacement-loop (D-loop) region. The D-loop is considered to be important because it controls mitochondrial gene expression and mtDNA replication. There is...

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Detalhes bibliográficos
Main Authors: Challen, C, Brown, H, Cai, C, Betts, G, Paterson, I, Sloan, P, West, C, Birch-Machin, M, Robinson, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078603/
https://ncbi.nlm.nih.gov/pubmed/21427725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.96
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