Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily in the heart and peripheral nervous system. Over 100 mutations of TTR have...

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Bibliografische gegevens
Hoofdauteurs: Noborn, Fredrik, O'Callaghan, Paul, Hermansson, Erik, Zhang, Xiao, Ancsin, John B., Damas, Ana M., Dacklin, Ingrid, Presto, Jenny, Johansson, Jan, Saraiva, Maria J., Lundgren, Erik, Kisilevsky, Robert, Westermark, Per, Li, Jin-Ping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078407/
https://ncbi.nlm.nih.gov/pubmed/21422279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101194108
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