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Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein
Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily in the heart and peripheral nervous system. Over 100 mutations of TTR have...
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| Glavni autori: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078407/ https://ncbi.nlm.nih.gov/pubmed/21422279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101194108 |
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