Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily in the heart and peripheral nervous system. Over 100 mutations of TTR have...

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Main Authors: Noborn, Fredrik, O'Callaghan, Paul, Hermansson, Erik, Zhang, Xiao, Ancsin, John B., Damas, Ana M., Dacklin, Ingrid, Presto, Jenny, Johansson, Jan, Saraiva, Maria J., Lundgren, Erik, Kisilevsky, Robert, Westermark, Per, Li, Jin-Ping
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078407/
https://ncbi.nlm.nih.gov/pubmed/21422279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101194108
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