Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily in the heart and peripheral nervous system. Over 100 mutations of TTR have...

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Bibliografski detalji
Glavni autori: Noborn, Fredrik, O'Callaghan, Paul, Hermansson, Erik, Zhang, Xiao, Ancsin, John B., Damas, Ana M., Dacklin, Ingrid, Presto, Jenny, Johansson, Jan, Saraiva, Maria J., Lundgren, Erik, Kisilevsky, Robert, Westermark, Per, Li, Jin-Ping
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078407/
https://ncbi.nlm.nih.gov/pubmed/21422279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101194108
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