Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol. Tetramer destabilization and misfolding of the released monomers result in TTR aggregation, leading to its deposition as amyloid primarily in the heart and peripheral nervous system. Over 100 mutations of TTR have...

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Главные авторы: Noborn, Fredrik, O'Callaghan, Paul, Hermansson, Erik, Zhang, Xiao, Ancsin, John B., Damas, Ana M., Dacklin, Ingrid, Presto, Jenny, Johansson, Jan, Saraiva, Maria J., Lundgren, Erik, Kisilevsky, Robert, Westermark, Per, Li, Jin-Ping
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078407/
https://ncbi.nlm.nih.gov/pubmed/21422279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101194108
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