Cancer-Associated Loss-of-Function Mutations Implicate DAPK3 as a Tumor Suppressing Kinase

Cancer kinome sequencing studies have identified several protein kinases predicted to possess driver (i.e. causal) mutations. Using bioinformatic applications we have pinpointed DAPK3 (ZIPK) as a novel cancer-associated kinase with functional mutations. Evaluation of nonsynonymous point mutations, d...

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Bibliographic Details
Main Authors: Brognard, John, Zhang, You-Wei, Puto, Lorena A., Hunter, Tony
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078168/
https://ncbi.nlm.nih.gov/pubmed/21487036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3543
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